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Welcome to the Scholpp lab

Signalling in neural development

News Ticker ……………………………………
* Jan 2017 - Simone has joined the team as a research technician. Welcome!
* Jan 2017 - Our lab has moved to the Living Systems Institute at the University of Exeter.
* Dec 2016 - Bernadett received her PhD degree.
* Feb 2016 - Our commentary on Wnt cytonemes has been published in JCS.
* Dec 2015 - Simone defended successfully her thesis.
* Oct 2015 - Yonglong has started his PhD project in the lab. Welcome and good luck!
* May 2015 - Good impact! Our articles have been cited over 1000 times!
* Apr 2015 - Simone's article has been published in Advanced Materials! Well done!
* Mar 2015 Radio report on Wnt cytonemes is online - only in German
* Feb 2015 Eliana received her PhD degree - with distinction!
* Jan 2015 - Eliana's article on Wnt cytonemes has been published in Nature Comms!
Find more news here.

Distribution of Wnts on cytonemes

Stanganello et al., Nature Communications, 2015

Research focus

Competence fields Developmental Neurobiology Cell biology Advanced Cell Culture Systems
We are interested in the early development of the brain and specifically how embryonic neural tissue acquires more complex organisation and function. Our particular interest is directed towards the development of the thalamus. We recently assigned a new organising function to the transverse Zona Limitans Intrathalamica boundary and termed it therefore as the mid-diencephalic organiser (MDO). This region expresses several important signalling molecules, including those of the Hedgehog and Wnt families. Through the release of these signaling factors, the MDO orchestrates the development of the thalamus. Secreted morphogens such as Shh and Wnt proteins are thought to spread through target tissues such as the thalamus and form long-range concentration gradients providing positional information. Recently we could show that Wnt signalling is important for the formation of the MDO, for compartition of the caudal forebrain and for neurogenesis in the thalamus. We want to understand how Wnt proteins are transported through a vertebrate tissue over hundreds of micrometers, and how transport mechanisms are linked to generation of an effective gradient. To date we have some understanding of the signalling pathways required for induction and regionalisation of the vertebrate brain, however, we are far from mimic this intricate process in vitro. In the complex environment of the intact embryo it is often too difficult to decipher the influence of multiple signals acting in a spatially and temporally controlled manner. Furthermore, advanced cell culture methods to generate such a tissue in vitro are lacking. Our goal is to develop a method to engineer a complex neuroepithelium in vitro.
Cooperation Partners Member of the DFG Forschergruppe 1036, Mechanisms, functions and evolution of Wnt signaling pathways
* James Y Li, Univesity of Connecticut
* Corinne Houart, MRC Centre for Neural Development
* Andrew Lumsden, MRC Centre for Neural Development
* Tom Kirchhausen, Harvard Medical School
* Herbert Steinbeisser Group, Uni Heidelberg
* Gary Davidson, ITG, KIT
* Matthias Carl, CBTM, Heidelberg
* Martin Bastmeyer, Dept Neuro & Cell Biol, ZOO, KIT
* Pavel Levkin, ITG, KIT
* Stefan Giselbrecht, IBG1, KIT
* Christopher Barner-Kowollik, OC, KIT
* Guillaume Delaittre, OC, KIT
Relevant Publications 2014: Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates; BMC Biol
2011: Lhx2 and Lhx9 Determine Neuronal Differentiation and Compartition in the Caudal Forebrain by Regulating Wnt Signaling; PLoS Biol
2015: Filopodia-based Wnt transport during vertebrate tissue patterning; Nat Comms
2014: In vivo analysis of formation and endocytosis of the Wnt/β-Catenin signaling complex in zebrafish embryos; JCS
2015: Photolithographic Patterning of 3D-Formed Polycarbonate Films for Targeted Cell Guiding. Adv Mater.
2013: Micropatterned superhydrophobic structures for the simultaneous culture of multiple cell types and the study of cell–cell communication; Biomaterials

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